Zika Virus Typing Tool

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Introduction

The definition of a Zika genotype is based on the identification of well defined phylogenetic clusters that its origin has been associated to a given geographic region.

We have carefully analysed all of ZIKV whole genomes and reviewed in the literature in order to represent the diversity of each phylotype. In addition, we performed extensive testing to be sure that our reference strains accurately classify other sequences. We found that the whole genome and the Envelope gene (E) gene to be suitable for classification.

We include 2 phylotypes
Phylotype 1 includes sequences from deferent African countries
Phylotype 2 includes sequences from Asian origin

Zika Virus phylogenetic tree — Fig. 1. Zika virus maximum likelihood phylogenetic tree of (A) complete genome and (B) E gene

Acknowledgements

Developed by: FIOCRUZ, Brazil (Vagner Fonseca, Marta Giovanetti, Maria Inês Restovic, Murilo Freire, Luiz Alcantara), KU Leuven, Belgium (Kristof Theys, Pieter Libin, Lize Cuypers, Ana Abecasis, Anne-Mieke Vandamme), University of Oxford, U.K. (Nuno Faria and Oliver Pybus), Evandro Chagas Institute, Pará, Brazil (Marcio Roberto Teixeira Nunes), CDC/OID/NCEZID (Gilberto A. Santiago), Emweb bvba, Belgium (Koen Deforche) and Krisp/UKZN, South Africa (Tulio de Oliveira).

Software: Genome Detective

Contact: Vagner Fonseca, Dr. Luiz Alcantara and/or Prof. Tulio de Oliveira