Genome Detective

Genome Detective offers intuitive Bio-Informatics applications for the analysis of microbial molecular sequence data.

We have published our first major application, Genome Detective Virus Tool: An Accurate, Fast and Automated System for Virus Identification from High-throughput next generation sequencing (NGS) data. Genome Detective Virus Tool accurately and quickly identifies, assembles and classifies all known viruses present in short read and long read that are produced by Illumina, Ion torrent and Oxford Nanopore sequencers.

COVID-19 and SARS-CoV-2

At Genome Detective, we have been following up on the COVID-19 outbreak since the first sequences for the SARS-CoV-2 virus have been made publicly available on the 11th of January 2020. We added some exciting new features to Genome Detective to support SARS-CoV-2 better.

The pan-viral Genome Detective Virus Tool was already sensitive enough to detected, assemble and assign SARS-CoV-2 at the species level as 'SARS-related coronavirus'.

On January 15th, the first test release of the Coronavirus typing tool was available. On the 31st of January, a full paper was deposited openly in biorxv. This paper received over 3,000 accessions and on the 17th of February was accepted for publication in the Bioinformatics journal - Sara Cleemput et al. Bioinformatics 2020.

All of our results and software were released in real-time and the Nature journalist Jack Leeming wrote an interesting article on Nature Index (February 26th) highlighting how our previous work on Yellow Fever Virus and Zika (published at Science and PLoS NTD) have prepared us to respond quickly to this coronavirus outbreak.

We have been improving Genome detective continuously, such as by improving mutation calling, and reassembly of raw viral Oxford Nanopore sequence data. UZLeuven used Genome Detective for confirming the diagnosis of the first Belgian SARS-CoV-2 infected patient, see use case in the video below.

The software was developed in collaboration with scientists and researchers from KRISP in South Africa, FioCruz in Brazil, and KULeuven/UZLeuven in Belgium.

Why choose Genome Detective?

Analyzing Next-Generation-Sequence meta-genomic datasets is increasingly complex due to large data files, the need for large and regularly updated reference databases, and complex bioinformatics processing. Using Genome Detective, you can quickly and easily extract accurate, meaningful information from your sequence data.

Ease of use

Ease of use

Requires no software installation nor detailed bioinformatics knowledge.

Insightful reports

Insightful reports

Alignment and coverage views provide visual confirmation of identified viruses.

Accurate

Accurate

We use manually curated reference databases and advanced methods to obtain high specificity with high sensitivity.

Assembly

Assembly

Using de novo assembly allows to type highly diverged viruses and results in (genome) sequences that can be further analyzed.

Subtyping

Subtyping

For several species, e.g. Human Immunodeficiency Virus 1, we work with the research community to create and maintain subtyping tools.

Contact us for more information
or a personalised quotation

We offer

Our Genome Detective Virus Tool is available online, or as locally installed software. Online, we offer you the option to evaluate the virus tool for free, or to subscribe to our premium package for routine use. The functionality and computing resources for the evaluation version are limited, but the identification and classification algorithms are the same for both versions. You are welcome to use our on line version or to contact us to design an on-premise installation for your lab or research group.

Evaluation version Premium account
Identify, assemble and classify all known viruses
Virus subtyping tools
Detailed reports
Always up to date
Batch uploads
Jobs are never queued
Commercial use allowed
No limit on storage space
Access to API

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